Concepedia

YTHDF1-enhanced iron metabolism depends on TFRC m<sup>6</sup>A methylation

Jing Ye, Zhanggui Wang, Xiaozhen Chen, Xiaohua Jiang, Zhihuai Dong, Sunhong Hu, Wenya Li, Yuehui Liu, Bing Liao, Weidong Han,

Theranostics · 2020 · 96 citations · 49 references

DOIFull text

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Concepts

Abstract

A-dependent mechanism. From a therapeutic perspective, targeting YTHDF1 and TFRC-mediated iron metabolism may be a promising strategy for HPSCC.

References

49

Cancer statistics, 2020

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2020 · 21.4K citations · Full text

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N6-methyladenosine-dependent regulation of messenger RNA stability

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Xiao Wang, Boxuan Zhao, Ian A. Roundtree et al. · Cell · 2015 · 3.6K citations · Full text

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Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang, Hengyou Weng, Wenju Sun et al. · Nature Cell Biology · 2018 · 3.1K citations

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MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients

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