Theranostics · 2020 · 109 citations · 31 references
MedicineOncologyPharmacologyDrug DiscoveryMolecular OncologySignal TransductionCancer Cell SignalingReceptor Tyrosine Kinase SignalingSignal Transduction In CancerTyrosine Kinase InhibitorsCell InvasionCell Viability AssaysDriver Oncogene IdentificationEgfr InhibitionLuciferase Reporter AssaysNon-small Cell Lung Cancer TherapyNon-small Cell Lung Cancer TreatmentStat3 Signaling
Our study has provided a novel STAT3 inhibitor with significant anti-tumor activities in NSCLC and suggests that combination of STAT3 inhibitor such as W2014-S with gefitinib could serve as a promising strategy to overcome EGFR-TKIs acquired resistance in NSCLC patients.
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Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization
Jochen Schust, Bianca Sperl, Angela Hollis et al. · Chemistry & Biology · 2006 · 1.1K citations
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Longchuan Bai, Haibin Zhou, Renqi Xu et al. · Cancer Cell · 2019 · 618 citations · Full text
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
Hui‐Wen Lo, Sheng-Chieh Hsu, Mohamed Ali‐Seyed et al. · Cancer Cell · 2005 · 538 citations · Full text