Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang, Chenwei Li, Chenwei Li et al. · Nucleic Acids Research · 2017 · 10.6K citations · Full text

Life Sciences, Bioinformatics, Cancer Biology +14

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Jason D. Buenrostro, Paul G. Giresi, Lisa C. Zaba et al. · Nature Methods · 2013 · 7K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics

Shao‐En Ong, Blagoy Blagoev, Irina Kratchmarova et al. · Molecular & Cellular Proteomics · 2002 · 5.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 5K citations

Life Sciences, Biotechnology, Molecular Biology +13

Full-length RNA-seq from single cells using Smart-seq2

Simone Picelli, Omid R. Faridani, Åsa K. Björklund et al. · Nature Protocols · 2014 · 4.5K citations

Life Sciences, Bioinformatics, Molecular Biology +7