Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Morgan D. Fullerton, Sandra Galić, Katarina Marcinko et al. · Nature Medicine · 2013 · 875 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

Lisa Pike, Amy Smift, Nicole J. Croteau et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2010 · 463 citations

Life Sciences, Biochemistry, Pharmacology +17

Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread

Sunila Pradeep, Seung Wook Kim, Sherry Y. Wu et al. · Cancer Cell · 2014 · 323 citations · Full text

Medicine, Gynecology, Oncology +14

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

Jun Hyoung Park, Sajna Antony Vithayathil, Santosh Kumar et al. · Cell Reports · 2016 · 319 citations · Full text

Life Sciences, Cell Biology, Oncology +17

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

Jonathan S. Oakhill, Zhiping Chen, John W. Scott et al. · Proceedings of the National Academy of Sciences · 2010 · 309 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17