Concepedia

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

Lisa Pike, Amy Smift, Nicole J. Croteau, David A. Ferrick, Min Wu

Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2010 · 463 citations · 25 references

DOI

Concepts

References

25

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

, , +12

On Respiratory Impairment in Cancer Cells

Otto Warbürg · Science · 1956 · 3.2K citations

, , +13

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Ralph J. DeBerardinis, Anthony Mancuso, Evgueni Daikhin et al. · Proceedings of the National Academy of Sciences · 2007 · 2.6K citations · Full text

, , +17

Production of large amounts of hydrogen peroxide by human tumor cells.

Ted P. Szatrowski, Carl Nathan · PubMed · 1991 · 2.5K citations

, , +17

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso et al. · Proceedings of the National Academy of Sciences · 2008 · 2K citations · Full text

, , +17