New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Alex B. Burgin, Ólafur Þ. Magnússon, Jasbir Singh et al. · Nature Biotechnology · 2009 · 394 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

Norbert Sommer, P.-A. Löschmann, G.H. Northoff et al. · Nature Medicine · 1995 · 346 citations

Medicine, Neuroscience, Pharmacology +12

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Annette Robichaud, Panagiota B. Stamatiou, S.-L. Catherine Jin et al. · Journal of Clinical Investigation · 2002 · 266 citations · Full text

Medicine, Anesthesiology, Pharmacology +10

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Annette Robichaud, Panagiota B. Stamatiou, S.-L. Catherine Jin et al. · Journal of Clinical Investigation · 2002 · 260 citations

Medicine, Anesthesiology, Pharmacology +10

Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect

James A. Cherry, Ronald L. Davis · The Journal of Comparative Neurology · 1999 · 210 citations

Medicine, Neurobiology, Neuroscience +13