A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

Katarzyna Wójcik‐Pszczoła, Grażyna Chłoń‐Rzepa, Agnieszka Jankowska, +9

International Journal of Molecular Sciences

Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation

Grażyna Chłoń‐Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryAnti-inflammatoryBiochemistryPotential Anti-inflammatory ActivityNatural Sciences +7

Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

Grażyna Chłoń‐Rzepa, Marietta Ślusarczyk, Agnieszka Jankowska, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)Health SciencesPain MedicinePde4/7 Inhibitors +13

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT_1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

Joanna Śniecikowska, Monika Głuch‐Lutwin, Adam Bucki, +14

Journal of Medicinal Chemistry

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity

Agnieszka Jankowska, Grzegorz Satała, Marcin Kołaczkowski, +12

European Journal of Medicinal Chemistry

Medicinal ChemistryNovel AnilideBiochemistryMedicineNatural Sciences +8

New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases

Veronika Ručilová, Artur Świerczek, David Vanda, +12

European Journal of Medicinal Chemistry

InflammationAutoimmune DiseaseAntiparasitic AgentMedicinePhosphodiesterase 4 +9

Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling

Katarzyna Wójcik‐Pszczoła, Grażyna Chłoń‐Rzepa, Agnieszka Jankowska, +10

European Journal of Pharmacology

Purine-2,6-dione DerivativesSignal TransductionMedicineMechanism Of ActionPharmacological Agent +8

Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents

Katarzyna Wójcik‐Pszczoła, Agnieszka Jankowska, Marietta Ślusarczyk, +10

Bioorganic Chemistry

Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin

Monika Kubacka, Magdalena Kotańska, Małgorzata Szafarz, +5

Nutrition Metabolism and Cardiovascular Diseases

Molecular PharmacologyHypertensionFructose-fed RatsNon-quinazoline α1-AdrenolyticsBeneficial Effects +8

Sensitive and precise HPLC method with back‐extraction clean‐up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study

Beata Strach, Elżbieta Wyska, Krzysztof Pociecha, +2

Biomedical Chromatography