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Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

Grażyna Chłoń‐Rzepa, Marietta Ślusarczyk, Agnieszka Jankowska, Alicja Gawalska, Adam Bucki, Marcin Kołaczkowski, Artur Świerczek, Krzysztof Pociecha, Elżbieta Wyska, Małgorzata Zygmunt,

European Journal of Medicinal Chemistry · 2018 · 36 citations · 43 references

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43

A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS

J.T. LITCHFIELD, Frank Wilcoxon · Journal of Pharmacology and Experimental Therapeutics · 1949 · 7.3K citations

, , +12

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

, , +7

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

Steinar Hunskaar, Kjell Hole · Pain · 1987 · 2.2K citations

, , +17

TRPA1 mediates formalin-induced pain

Colleen R. McNamara, Josh Mandel-Brehm, Diana M. Bautista et al. · Proceedings of the National Academy of Sciences · 2007 · 1.3K citations · Full text

, , +17

Structure of the TRPA1 ion channel suggests regulatory mechanisms

Candice E. Paulsen, Jean‐Paul Armache, Yuan Gao et al. · Nature · 2015 · 669 citations · Full text

, , +13