Concepedia

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes, Walid Warda, Elizabeth Pöhler, Paul K. Fyfe, Adeline Cozzani, Christophe Ferrand, Mark R. Walter, Suman Mitra,

Science Signaling · 2020 · 84 citations · 53 references

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Abstract

T cells. Moreover, CAR-modified T cells expanded with the engineered IL-10 variant displayed superior cytolytic activity than those expanded with wild-type IL-10. Our study provides insights into how IL-10 receptor complex stability fine-tunes IL-10 biology and opens new opportunities to revitalize failed IL-10 therapies.

References

53

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang, Brad T. Sherman, Richard A. Lempicki · Nature Protocols · 2008 · 37.4K citations

, , +5

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Da Wei Huang, Brad T. Sherman, Richard A. Lempicki · Nucleic Acids Research · 2008 · 14.7K citations · Full text

, , +8

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

René de Waal Malefyt, J S Abrams, B Bennett et al. · The Journal of Experimental Medicine · 1991 · 3.8K citations · Full text

, , +10

IL-10 inhibits cytokine production by activated macrophages

David Fiorentino, Albert Zlotnik, Tim R. Mosmann et al. · The Journal of Immunology · 1991 · 2.9K citations · Full text

, , +16

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

, , +15