Concepedia

Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors

Lamya H. Al-Wahaibi, Ahmed M. Gouda, Ola F. Abou‐Ghadir, Ola I. A. Salem, Asmaa T. Ali, Hatem S. Farghaly, Mostafa Abdelrahman, Laurent Trembleau, Hajjaj H.M. Abdu-Allah, Bahaa G. M. Youssif

Bioorganic Chemistry · 2020 · 76 citations · 36 references

DOI

Concepts

References

36

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry · 2009 · 25K citations · Full text

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

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Vemurafenib in Multiple Nonmelanoma Cancers with <i>BRAF</i> V600 Mutations

David M. Hyman, Igor Puzanov, Vivek Subbiah et al. · New England Journal of Medicine · 2015 · 1.7K citations · Full text

, , +12

Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

Jennifer L. Stamos, Mark X. Sliwkowski, Charles Eigenbrot · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

, , +16

Synergistic drug combinations tend to improve therapeutically relevant selectivity

Joseph Lehár, Andrew Krueger, William Avery et al. · Nature Biotechnology · 2009 · 957 citations · Full text

, , +13