Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Pathology, Cancer Biology, Cancer Chemotherapy +17

The entry of nanoparticles into solid tumours

Shrey Sindhwani, Abdullah M. Syed, Jessica Ngai et al. · Nature Materials · 2020 · 1.5K citations

Nanoparticles, Nanomedicine, Engineering +5

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Uma Prabhakar, Hiroshi Maeda, Rakesh K. Jain et al. · Cancer Research · 2013 · 1.4K citations

Nanoparticles, Workshop Discussions, Engineering +18

Tumoritropic and lymphotropic principles of macromolecular drugs.

Hiroshi Maeda, Yasuhiro Matsumura · PubMed · 1989 · 580 citations

Medicinal Chemistry, Mw 16, Drug Targeting +13

Therapeutic targeting of the tumor microenvironment

Johanna A. Joyce · Cancer Cell · 2005 · 578 citations · Full text

Drug Targeting, Biological Microenvironments, Tumor Targeting +6