Concepedia

Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants

Beilei Wang, Wentao Zhang, Xuesong Liu, Fengming Zou, Jun‐Jie Wang, Qingwang Liu, Qingwang Liu, Aoli Wang, Zhenquan Hu, Yongfei Chen,

European Journal of Medicinal Chemistry · 2020 · 18 citations · 21 references

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References

21

Efficacy of Larotrectinib in <i>TRK</i> Fusion–Positive Cancers in Adults and Children

Alexander Drilon, Theodore W. Laetsch, Shivaani Kummar et al. · New England Journal of Medicine · 2018 · 2.7K citations · Full text

, , +16

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

, , +12

Rational design of inhibitors that bind to inactive kinase conformations

Yi Liu, Nathanael S. Gray · Nature Chemical Biology · 2006 · 1.1K citations · Full text

, , +14

The landscape of kinase fusions in cancer

Nicolas Stransky, Ethan Cerami, Stefanie S. Schalm et al. · Nature Communications · 2014 · 969 citations · Full text

, , +17

Aromatic rings act as hydrogen bond acceptors

Michael Levitt, M. F. Perutz · Journal of Molecular Biology · 1988 · 696 citations

, , +9