Concepedia

Polyamine pathway activity promotes cysteine essentiality in cancer cells

Tong Zhang, Christin Bauer, Alice C. Newman, Alejandro Huerta Uribe, Dimitris Athineos, Karen Blyth, Oliver D.K. Maddocks

Nature Metabolism · 2020 · 60 citations · 48 references

DOI

Concepts

References

48

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 18.1K citations · Full text

, , +10

HMDB 4.0: the human metabolome database for 2018

David S. Wishart, Yannick Djoumbou-Feunang, Ana Marcu et al. · Nucleic Acids Research · 2017 · 3.6K citations · Full text

, , +17

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang, Katherine J. Kim, Michael M. Gaschler et al. · Proceedings of the National Academy of Sciences · 2016 · 2.3K citations · Full text

, , +17

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature · 2011 · 2.2K citations · Full text

, , +14

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Scott J. Dixon, Darpan N. Patel, Matthew Welsch et al. · eLife · 2014 · 2.1K citations · Full text

, , +13