Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

William Pao, Vincent A. Miller, Katerina Politi et al. · PLoS Medicine · 2005 · 3.5K citations · Full text

Medicine, Oncology, Pharmacology +17

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Bryan Lanning, Landon R. Whitby, Melissa M. Dix et al. · Nature Chemical Biology · 2014 · 363 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +15

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Mark E. Flanagan, J. A. Abramite, Dennis P. Anderson et al. · Journal of Medicinal Chemistry · 2014 · 324 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

Emmanouil Fokas, Jae Hong Im, Sally A. Hill et al. · Cancer Research · 2011 · 128 citations

Medicine, Pharmacology, Cancer Pharmacology +13

Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

Zhendong Song, Ge Yang, Changyuan Wang et al. · Journal of Medicinal Chemistry · 2016 · 103 citations · Full text

Medicine, Oncology, Pharmacology +15