Concepedia

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells

Mittal Shah, Asher Maroof, Panos Gikas, Gayatri Mittal, Richard Keen, Dominique Baeten, Stevan Shaw, Scott J. Roberts

RMD Open · 2020 · 53 citations · 21 references

DOIFull text

Open access

Abstract

These data show for the first time that IL-17A and IL-17F enhance in vitro osteogenic differentiation and bone formation from hPDCs, inhibition of which may offer an attractive therapeutic strategy to prevent pathological bone formation.

References

21

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

Harumichi Ishigame, Shigeru Kakuta, Takeshi Nagai et al. · Immunity · 2009 · 1K citations · Full text

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Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age

Cosimo De Bari, Francesco Dell’Accio, Frank P. Luyten · Arthritis & Rheumatism · 2001 · 532 citations

IL-17-producing γδ T cells enhance bone regeneration

T. Ono, Kazuo Okamoto, Tomoki Nakashima et al. · Nature Communications · 2016 · 351 citations · Full text

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

Sophie Glatt, Dominique Baeten, Terry Baker et al. · Annals of the Rheumatic Diseases · 2017 · 249 citations · Full text

High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis

Gisela Ruiz Heiland, Heiner Appel, Denis Poddubnyy et al. · Annals of the Rheumatic Diseases · 2011 · 240 citations · Full text