Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka, Markus P. Kummer, Andrea Stutz et al. · Nature · 2012 · 2.9K citations · Full text

Life Sciences, Neurology, Neuroscience +14

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle, Veit Hornung, Gabor C. Petzold et al. · Nature Immunology · 2008 · 2.4K citations · Full text

Life Sciences, Cell Biology, Immunology +13

Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

Tarek A. Samad, Kimberly A. Moore, Adam Sapirstein et al. · Nature · 2001 · 1.3K citations

Life Sciences, Immunology, Neurobiology +14

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

Michael T. Heneka, Magdalena Sastre, Lucia Dumitrescu‐Ozimek et al. · Brain · 2005 · 559 citations · Full text

Medicine, Neuroscience, Pharmacology +17

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

Marina Saresella, Francesca La Rosa, Federica Piancone et al. · Molecular Neurodegeneration · 2016 · 485 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17