Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai et al. · Proceedings of the National Academy of Sciences · 2001 · 2.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Light-Induced Protein Degradation with Photocaged PROTACs

Gang Xue, Kun Wang, Danli Zhou et al. · Journal of the American Chemical Society · 2019 · 344 citations

Life Sciences, Biochemistry, Molecular Biology +15

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

Mengchen Lu, Tian Liu, Qiong Jiao et al. · European Journal of Medicinal Chemistry · 2018 · 292 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Chiara Maniaci, Scott J. Hughes, Andrea Testa et al. · Nature Communications · 2017 · 238 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK)

Chengwei Zhang, Xiaoran Han, Xiaobao Yang et al. · European Journal of Medicinal Chemistry · 2018 · 218 citations · Full text

Medicine, Cancer Biology, Oncology +12