Concepedia

Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis

Tao Liu, Qunfang Yang, Xuan Zhang, Rongxing Qin, Wenjun Shan, Haigang Zhang, Xiaohong Chen

Life Sciences · 2020 · 157 citations · 49 references

DOI

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49

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Christopher D. Wiley, Michael C. Velarde, Pacôme Lecot et al. · Cell Metabolism · 2015 · 1.2K citations · Full text

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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Jamie N. Justice, Anoop M. Nambiar, Tamar Tchkonia et al. · EBioMedicine · 2019 · 1.2K citations · Full text

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

João F. Passos, Glyn Nelson, Chunfang Wang et al. · Molecular Systems Biology · 2010 · 996 citations · Full text

, , +13

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Joon-Il Jun, Lester F. Lau · Nature Cell Biology · 2010 · 960 citations · Full text

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