Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.3K citations

Natural Sciences, Rna Splicing, Rna Biology +9

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Pathology, Cancer Biology, Cancer Chemotherapy +17

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck, Leila Akkari, Alberto J. Schuhmacher et al. · Nature Medicine · 2013 · 2.4K citations · Full text

Neuro-oncology, Glioma, Medicine +8

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

Horacio Cabral, Yu Matsumoto, Kazue Mizuno et al. · Nature Nanotechnology · 2011 · 2.4K citations

Nanomedicine, Engineering, Permeable Tumours +8

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

David G. DeNardo, Donal J. Brennan, Elton Rexhepaj et al. · Cancer Discovery · 2011 · 1.7K citations · Full text