Concepedia

Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice

Yun Cao, Bingjin Liu, Weiqi Xu, Lin Wang, Fang-Xiao Shi, Na Li, Ying Lei, Jian‐Zhi Wang, Qing Tian, Xinwen Zhou

Brain Research Bulletin · 2020 · 13 citations · 39 references

DOI

Concepts

References

39

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe et al. · Nature · 2004 · 1.7K citations · Full text

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Laura Harrington, Greg M. Findlay, Simon Wigfield et al. · The Journal of Cell Biology · 2004 · 1.1K citations · Full text

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Akt regulates growth by directly phosphorylating Tsc2

Christopher J. Potter, Laura G. Pedraza, Tian Xu · Nature Cell Biology · 2002 · 953 citations

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A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat

Michael Reed, Karl Meszaros, L. J. Entes et al. · Metabolism · 2000 · 848 citations

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