Concepedia

Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo

Nannan Tian, Huanxian Wu, Huiwu Zhang, Danni Yang, Lin Lv, Zichao Yang, Tingting Zhang, Dongling Quan, Lei Zhou, Ying Xie,

Bioorganic & Medicinal Chemistry · 2020 · 12 citations · 18 references

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18

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

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Vertebrate Smoothened functions at the primary cilium

Kevin C. Corbit, Pia Aanstad, Veena Singla et al. · Nature · 2005 · 1.5K citations

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text

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Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Aurélie Cazet, Mun N. Hui, Benjamin Elsworth et al. · Nature Communications · 2018 · 442 citations · Full text

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Structural basis of Smoothened regulation by its extracellular domains

Eamon F.X. Byrne, Ria Sircar, Paul S. Miller et al. · Nature · 2016 · 369 citations · Full text

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