Structural basis of Smoothened regulation by its extracellular domains

Eamon F.X. Byrne, Ria Sircar, Paul S. Miller, +11

Nature

Signal TransductionMolecular PhysiologyMolecular RegulationCellular Regulatory MechanismCytoskeleton +8

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Giovanni Luchetti, Ria Sircar, Jennifer H. Kong, +6

eLife

HyperlipidemiaLipid MovementCellular PhysiologySignaling PathwayCell Signaling +14

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

Ganesh V. Pusapati, Jennifer H. Kong, Bhaven B. Patel, +7

Science Signaling

Co-Folding of a FliF-FliG Split Domain Forms the Basis of the MS:C Ring Interface within the Bacterial Flagellar Motor

Michael J. Lynch, Robert Levenson, Eun A Kim, +4

Structure

BacteriologyBacteriophageMolecular BiologyStructural BiologyMicrobiology +5

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, +8

eLife

Proteinlipid InteractionCholesterol AccessibilityOuter LeafletLipid MovementCellular Physiology +17

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

Maia Kinnebrew, Rachel E. Woolley, T. Bertie Ansell, +12

Science Advances

Ligand Sonic HedgehogLipid MovementCellular PhysiologySignaling PathwayCell Signaling +16

Architecture of the Soluble Receptor Aer2 Indicates an In-Line Mechanism for PAS and HAMP Domain Signaling

Michael V. Airola, Doowon Huh, Nattakan Sukomon, +6

Journal of Molecular Biology

Signal TransductionSignaling PathwayMolecular PathwayG Protein-coupled ReceptorReceptor (Biochemistry) +8

Structure and Activity of the Flagellar Rotor Protein FliY

Ria Sircar, Anna R. Greenswag, A.M. Bilwes, +2

Journal of Biological Chemistry

Assembly States of FliM and FliG within the Flagellar Switch Complex

Ria Sircar, Peter P. Borbat, Michael J. Lynch, +5

Journal of Molecular Biology

Flagellar Switch ComplexBiophysicsMolecular Biology

Self-Association of the Histidine Kinase CheA as Studied by Pulsed Dipolar ESR Spectroscopy

Jaya Bhatnagar, Ria Sircar, Peter P. Borbat, +2

Biophysical Journal

Signal TransductionDipolar Esr SpectroscopyBiochemistryNatural SciencesBiomolecular Analysis +6