Giovanni Luchetti

Structural basis of Smoothened regulation by its extracellular domains

Eamon F.X. Byrne, Ria Sircar, Paul S. Miller et al. · Nature · 2016 · 358 citations · Full text

Signal Transduction, Molecular Physiology, Molecular Regulation +10

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Giovanni Luchetti, Ria Sircar, Jennifer H. Kong et al. · eLife · 2016 · 240 citations · Full text

Hyperlipidemia, Lipid Movement, Cellular Physiology +16

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

Giovanni Luchetti, Justin L. Roncaioli, Roberto A. Chavez et al. · Cell Host & Microbe · 2021 · 175 citations · Full text

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Maia Kinnebrew, Ellen J. Iverson, Bhaven B. Patel et al. · eLife · 2019 · 148 citations · Full text

Proteinlipid Interaction, Cholesterol Accessibility, Lipid Movement +16

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

Ganesh V. Pusapati, Jennifer H. Kong, Bhaven B. Patel et al. · Science Signaling · 2018 · 100 citations · Full text