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Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization

Jaspreet Banga, Dinesh Srinivasan, Chia-Chi Sun, Cherrie D. Thompson, Francesca Milletti, Kuo‐Sen Huang, Shannon Hamilton, Su Song, Ann F. Hoffman, Yajuan Qin,

Science Advances · 2020 · 29 citations · 64 references

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Concepts

Abstract

)IRF5], with no effect on pIRF5 levels. These data support that IRF5-CPPs function downstream of phosphorylation. Together, data support the utility of IRF5-CPPs as novel tools to probe IRF5 activation and function in disease.

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