SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis

Local regulation of gene expression by lncRNA promoters, transcription and splicing

J Engreitz, Jenna E. Haines, Elizabeth M. Perez et al. · Nature · 2016 · 1.3K citations · Full text

Transcriptional Regulation, Developmental Biology, Genetics +11

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

C. Theresa Vincent, Etienne P.A. Neve, Jill R. Johnson et al. · Nature Cell Biology · 2009 · 631 citations · Full text

Epithelial-mesenchymal Transition, Transcriptional Regulation, Developmental Biology +12

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Hanane Laklai, Yekaterina A. Miroshnikova, Michael W. Pickup et al. · Nature Medicine · 2016 · 583 citations · Full text

Fibrosis, Pancreatic Cancer, Tumor Progression +8

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Zhihu Ding, Chang‐Jiun Wu, Gerald C. Chu et al. · Nature · 2011 · 522 citations · Full text

Medicine, Prostatic Disease, Cancer Biology +3

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Julia Joung, J Engreitz, Silvana Konermann et al. · Nature · 2017 · 432 citations

Chromatin, Genome-scale Activation Screen, Lncrna Locus +9