Concepedia

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

Charles N. Birts, Arindam Banerjee, Matthew Darley, Charles R. Dunlop, Sarah J. Nelson, Sharandip K. Nijjar, Rachel Parker, Jonathan West, Ali Tavassoli, Matthew Rose‐Zerilli,

Science Signaling · 2020 · 54 citations · 42 references

DOIFull text

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Concepts

Abstract

ratio enables cells to avoid cellular damage caused by mismatches between metabolic supply and demand.

References

42

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko, Anindita Basu, Rahul Satija et al. · Cell · 2015 · 7.8K citations · Full text

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Richard Possemato, Kevin M. Marks, Yoav D. Shaul et al. · Nature · 2011 · 1.7K citations · Full text

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin, Julie St‐Pierre, Philip Leder · Cancer Cell · 2006 · 1.6K citations · Full text

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AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint

Russell G. Jones, David R. Plas, Sara Kubek et al. · Molecular Cell · 2005 · 1.6K citations · Full text

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