Hdm2 Recruits a Hypoxia-Sensitive Corepressor to Negatively Regulate p53-Dependent Transcription

Alexander Mirnezami, Sandra J. Campbell, Matthew Darley, +3

Current Biology

Transcriptional RegulationSystems BiologyRedox RegulatorHypoxia (Medicine)Hypoxia-sensitive Corepressor +4

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

Monika Phelps, Matthew Darley, John Primrose, +1

PubMed

Breast OncologyCell DeathP53-independent ActivationCancer BiologyTumor Biology +17

Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance

Charles N. Birts, Rachael Harding, Gehan Soosaipillai, +6

Biology of the Cell

MEK-ERK Signaling Controls Hdm2 Oncoprotein Expression by Regulating hdm2 mRNA Export to the Cytoplasm

Monika Phelps, Anna Phillips, Matthew Darley, +1

Journal of Biological Chemistry

CtBPs Promote Cell Survival through the Maintenance of Mitotic Fidelity

Lee Bergman, Charles N. Birts, Matthew Darley, +2

Molecular and Cellular Biology

ApoptosisCell DeathCell CycleCancer BiologyCellular Physiology +16

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

Anna Phillips, Amina F.A.S. Teunisse, Suzanne Lam, +12

Journal of Biological Chemistry

Molecular RegulationEpigenetic ChangeGeneticsApoptosisMolecular Biology +19

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

Charles N. Birts, Arindam Banerjee, Matthew Darley, +8

Science Signaling

Stem cell-like breast cancer cells with acquired resistance to metformin are sensitive to inhibitors of NADH-dependent CtBP dimerization

Arindam Banerjee, Charles N. Birts, Matthew Darley, +7

Carcinogenesis

Breast OncologyChemoprevention StrategyMetabolic RemodelingCancer BiologyTumor Biology +15

Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

Lee Bergman, Laila Rhee Morris, Matthew Darley, +3

BMC Cell Biology

Protein FunctionSignal TransductionSignaling PathwayCtbp Family ProteinsNatural Sciences +9

GC-selective DNA-binding antibiotic, Mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis

Anna Phillips, Matthew Darley, Jeremy P. Blaydes

Oncogene

EngineeringMolecular RegulationNatural SciencesProtein BiosynthesisMolecular Biology +10