Concepedia

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure–Activity Relationship Studies of <i>N</i>-Phenethyl-α-methyl-pantothenamide

Christina Spry, Leanne Barnard, Michélle Kok, Andrew K. Powell, Darvina Mahesh, Erick T. Tjhin, Kevin J. Saliba, Erick Strauss, Marianne de Villiers

ACS Infectious Diseases · 2020 · 23 citations · 26 references

DOI

Concepts

Abstract

-diastereomer suggested species-dependent degradation via amide hydrolysis. Our study provides important information for the continued development of PanAm-based antimalarials.

References

26

World malaria report

Weltgesundheitsorganisation · 2005 · 3.8K citations

A NEW REAGENT FOR THE DETERMINATION OF SUGARS

Michael Somogyi · Journal of Biological Chemistry · 1945 · 2.5K citations · Full text

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Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

, , +16

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Ina Hubatsch, Eva Ragnarsson, Per Artursson · Nature Protocols · 2007 · 1.5K citations

, , +14

Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening

Martin J. Smilkstein, Nongluk Sriwilaijaroen, Jane X. Kelly et al. · Antimicrobial Agents and Chemotherapy · 2004 · 1.2K citations · Full text

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