Marianne de Villiers

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

Hans Raj, Wiktor Szymański, Jandré de Villiers et al. · Nature Chemistry · 2012 · 92 citations

Biosynthesis, Engineering, Methylaspartate Ammonia Lyase +10

Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

Marianne de Villiers, Cristiano Macuamule, Christina Spry et al. · ACS Medicinal Chemistry Letters · 2013 · 57 citations · Full text

Improves Antiplasmodial Activity, Potent Analogues, Pantothenamide Analogues +15

Catalytic Mechanisms and Biocatalytic Applications of Aspartate and Methylaspartate Ammonia Lyases

Marianne de Villiers, Vinod Puthan Veetil, Hans Raj et al. · ACS Chemical Biology · 2012 · 52 citations

Engineering, Enzymatic Modification, Biosynthesis +16

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis

Marianne de Villiers, Leanne Barnard, L. Koekemoer et al. · FEBS Journal · 2014 · 36 citations · Full text

Engineering, Molecular Biology, Chemical Biology +18

A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity

Cristiano Macuamule, Erick T. Tjhin, Collins E. Jana et al. · Antimicrobial Agents and Chemotherapy · 2015 · 36 citations · Full text