Concepedia

Phenyl Ring Replacement

Phenyl Ring Replacement is a bioisosteric strategy in medicinal chemistry wherein a phenyl ring is substituted with a structurally distinct ring system to modulate physicochemical, pharmacokinetic, or pharmacodynamic properties while retaining or enhancing biological activity.

671

Publications

29.4K

Citations

3.9K

Authors

863

Institutions

Publications per year

2017–2026

90

Parents

Publications

671

Interactions of Heteroaromatic Compounds with Nucleic Acids

Wernér E.G. Müller, Donald M. Crothers · European Journal of Biochemistry · 1975 · 343 citations · Full text

, , +17

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Alexander J. Bridges, Hairong Zhou, Donna R. Cody et al. · Journal of Medicinal Chemistry · 1996 · 322 citations · Full text

, , +17

Electrochemical bandgaps of substituted polythiophenes

Tomas Johansson, Wendimagegn Mammo, Mattias Svensson et al. · Journal of Materials Chemistry · 2003 · 311 citations

, , +15

Alkaline Stable C2-Substituted Imidazolium-Based Anion-Exchange Membranes

Bencai Lin, Huilong Dong, Youyong Li et al. · Chemistry of Materials · 2013 · 308 citations

, , +17

The Discovery of Tadalafil:  A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-<i>b</i>]indole-1,4-dione Analogues

Alain Daugan, Pascal Grondin, Cécile Ruault et al. · Journal of Medicinal Chemistry · 2003 · 282 citations · Full text

, , +17

1–5 of 671

Authors

3.9K

  1. DP
    Damian Pociecha

    University of Warsaw, Poland

    6 publications · 156 citations

    6

    h-index

  2. EN
    Ettore Novellino

    University of Naples Federico II, Italy

    5 publications · 214 citations

    5

    h-index

  3. FD
    Federico Da Settimo

    University of Pisa, Italy

    5 publications · 214 citations

    5

    h-index

  4. MB
    Masanori Baba

    Kagoshima University, Japan

    4 publications · 286 citations

    4

    h-index

  5. ST
    Sabrina Taliani

    University of Pisa, Italy

    4 publications · 162 citations

    4

    h-index

1–5 of 3.9K

Institutions

863

  1. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    124 publications

    6.2K citations

  2. University of Pisa

    Pisa, Italy

    7 h-index

    68 publications

    2.7K citations

  3. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    33 publications

    1.2K citations

  4. South China University of Technology

    Guangzhou, China

    6 h-index

    26 publications

    840 citations

  5. National Institutes of Health

    Bethesda, United States

    6 h-index

    34 publications

    2.1K citations

  6. University of Warsaw

    Warsaw, Poland

    6 h-index

    14 publications

    336 citations

  7. University of Ferrara

    Ferrara, Italy

    6 h-index

    49 publications

    2.6K citations

  8. University of Auckland

    Auckland, New Zealand

    6 h-index

    39 publications

    5.4K citations

1–8 of 863

Venues

  1. Journal of Medicinal Chemistry

    135 publications · 8.6K citations

    56

    h-index

  2. Inorganic Chemistry

    18 publications · 908 citations

    15

    h-index

  3. The Journal of Organic Chemistry

    JOC · 16 publications · 755 citations

    14

    h-index

  4. Bioorganic & Medicinal Chemistry

    13 publications · 529 citations

    12

    h-index

  5. Organic & Biomolecular Chemistry

    12 publications · 392 citations

    11

    h-index

1–5