The impact of hyperglycaemia on PKM2-mediated NLRP3 inflammasome/stress granule signalling in macrophages and its correlation with plaque vulnerability: an in vivo and in vitro study

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel et al. · Cell Metabolism · 2015 · 1.3K citations · Full text

Inflammation, Cytokine, Pyruvate Kinase M2 +10

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Min Xie, Yan Yu, Rui Kang et al. · Nature Communications · 2016 · 538 citations · Full text

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

Tsuyoshi Shirai, Rafal R. Nazarewicz, Barbara B. Wallis et al. · The Journal of Experimental Medicine · 2016 · 525 citations · Full text

Immunology, Metabolic Remodeling, Coronary Artery Disease +21

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

Parimal Samir, Sannula Kesavardhana, Deanna M. Patmore et al. · Nature · 2019 · 410 citations · Full text

Inflammation, Cell Regulation, Apoptosis +10

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei, Alexander Becher, Konrad Steinestel et al. · Molecular Cancer · 2016 · 322 citations · Full text