NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

Margit A. Huber, Ninel Azoitei, Bernd Baumann, +6

Journal of Clinical Investigation

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

Margit A. Huber, Ninel Azoitei, Bernd Baumann, +6

Journal of Clinical Investigation

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei, Alexander Becher, Konrad Steinestel, +5

Molecular Cancer

Variant classification in precision oncology

Jonas Leichsenring, Peter Horak, Simon Kreutzfeldt, +39

International Journal of Cancer

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, +22

Cancer Research

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Markus Breunig, Jessica Merkle, Martin Wagner, +34

Cell stem cell

Tissue EngineeringRegenerative MedicinePancreatic Ductal OrganoidsInduced Pluripotent Stem CellDevelopmental Biology +10

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33

Ninel Azoitei, Christopher M. Hoffmann, Jana M. Ellegast, +13

The Journal of Experimental Medicine

Systems BiologyKras Mutant TumorsHsp90 InhibitorsMedicineReceptor Tyrosine Kinase +11

Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by Suppression of Phosphatidylcholine Hydroperoxide-mediated NFκB Activation and Interleukin-6 Release

Jutta Wenk, Jutta Schüller, Christina Hinrichs, +15

Journal of Biological Chemistry

Interstitial Collagenase/matrix Metalloproteinase-1Lipid PeroxidationImmunologyInterleukin-6 ReleaseCell Death +20

Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure

Milena Armacki, Anna Katharina Trugenberger, Ann K. Ellwanger, +31

Journal of Clinical Investigation

Chronic Inflammatory DiseasesApoptosisImmunologyGastroenterologyCell Death +25

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

Johann Gout, Lukas Perkhofer, Mareen Morawe, +27

Gut