Aging · 2020 · 113 citations · 59 references
Life SciencesGeneticsMolecular BiologyAgingGene ExpressionInflammationBiological AgingCellular AgingCellular SenescenceDna Damage SignalingGenetics Of AgingInflammatory SignalingAging-related PathologyAtaxia-telangiectasia Mutated SignalingAtm Kinase SignalingCellular Senescence MarkersDna Damage Response SignalingDna Damage-induced SenescenceNf-κb SignalingStem Cell Dysfunction
mice with the ATM inhibitor KU-55933 suppressed markers of senescence and SASP. Taken together, these results demonstrate that the ATM kinase is a major mediator of DNA damage-induced, NF-κB-mediated cellular senescence, stem cell dysfunction and aging and thus represents a therapeutic target to slow the progression of aging.
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