Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor, Y. Bill Kim, Michael S. Packer, +2

Nature

EngineeringGeneticsSynthetic BiologyMolecular BiologyDna Replication +9

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis, +8

Nature

Genome SurgeryMedicineGeneticsMolecular BiologyGenetic Engineering +3

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, +4

Nature

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

Yanpeng Wang, Xi Cheng, Qiwei Shan, +4

Nature Biotechnology

BiologyEngineeringGeneticsCrop ProtectionPlant Protection +7

Genomic variation in 3,010 diverse accessions of Asian cultivated rice

Wensheng Wang, Ramil Mauleon, Zhiqiang Hu, +67

Nature

A CRISPR/Cas9 toolkit for multiplex genome editing in plants

Hui-Li Xing, Dong Li, Zhi-Ping Wang, +5

BMC Plant Biology

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

Keiji Nishida, Takayuki Arazoe, Nozomu Yachie, +9

Science

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

Yuan Zong, Yanpeng Wang, Chao Li, +6

Nature Biotechnology

Plant Molecular BiologyBiosynthesisEngineeringPrecise BaseBiotechnology +9

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Y. Bill Kim, Alexis C. Komor, Jonathan M. Levy, +3

Nature Biotechnology

EngineeringCas9-cytidine Deaminase FusionsSynthetic BiologyGenetic EngineeringMolecular Biology +8

Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA

Sergei Svitashev, Joshua K. Young, Christine Schwartz, +3

PLANT PHYSIOLOGY

Guide RnaGeneticsGenetic EngineeringMolecular BiologyPrecise Gene Editing +10