Concepedia

Prime Editing-mediated Insertion

Prime Editing-Mediated Insertion is a gene knock-in strategy that utilizes a prime editing system—comprising a catalytically impaired Cas9 fused to a reverse transcriptase and a prime editing guide RNA—to directly write specified DNA sequences into targeted genomic loci with high precision and minimal reliance on endogenous DNA repair pathways.

28

Publications

3.4K

Citations

259

Authors

90

Institutions

Publications per year

2017–2026

28

Parents

Publications

28

Prime genome editing in rice and wheat

Qiupeng Lin, Yuan Zong, Chenxiao Xue et al. · Nature Biotechnology · 2020 · 869 citations

, , +11

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

Andrew V. Anzalone, Xin D. Gao, Christopher J. Podracky et al. · Nature Biotechnology · 2021 · 573 citations · Full text

, , +11

Phage-assisted evolution and protein engineering yield compact, efficient prime editors

Jordan L. Doman, Smriti Pandey, Monica E. Neugebauer et al. · Cell · 2023 · 285 citations · Full text

, , +17

Improving prime editing with an endogenous small RNA-binding protein

Jun Yan, Paul Oyler, Purnima Ravisankar et al. · Nature · 2024 · 221 citations · Full text

, , +14

Deletion and replacement of long genomic sequences using prime editing

Tingting Jiang, Xiao‐Ou Zhang, Zhiping Weng et al. · Nature Biotechnology · 2021 · 189 citations · Full text

, , +8

1–5 of 28

Authors

259

  1. BM
    Beth Martin

    University of Washington, United States

    3 publications · 93 citations

    3

    h-index

  2. JC
    Junhong Choi

    Stanford University, United States

    3 publications · 93 citations

    3

    h-index

  3. WC
    Wei Chen

    University of Washington, United States

    3 publications · 93 citations

    3

    h-index

  4. AR
    Aditya Raguram

    Howard Hughes Medical Institute, United States

    3 publications · 1.7K citations

    3

    h-index

  5. JS
    Jay Shendure

    University of Washington, United States

    3 publications · 93 citations

    3

    h-index

1–5 of 259

Institutions

90

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    34 publications

    12.8K citations

  2. Broad Institute

    Cambridge, United States

    5 h-index

    30 publications

    13.1K citations

  3. Harvard University

    Cambridge, United States

    5 h-index

    29 publications

    12.6K citations

  4. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    26 publications

    7.5K citations

  5. Brotman Baty Institute

    Seattle, United States

    3 h-index

    4 publications

    145 citations

  6. University of Chinese Academy of Sciences

    Beijing, China

    3 h-index

    16 publications

    5.4K citations

  7. Cornell University

    Ithaca, United States

    3 h-index

    21 publications

    891 citations

  8. University of Washington

    Seattle, United States

    3 h-index

    36 publications

    1.2K citations

1–8 of 90

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 5 publications · 132 citations

    5

    h-index

  2. Nature Communications

    4 publications · 235 citations

    4

    h-index

  3. Nature Biotechnology

    4 publications · 1.7K citations

    4

    h-index

  4. Nature

    2 publications · 273 citations

    2

    h-index

  5. Nucleic Acids Research

    2 publications · 110 citations

    2

    h-index

1–5