Concepedia

Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors

Ahmed K. ElHady, Shou‐Ping Shih, Yu-Cheng Chen, Yi‐Chang Liu, Nermin S. Ahmed, Adam B. Keeton, Gary A. Piazza, Matthias Engel, Mohammad Abdel‐Halim

Bioorganic Chemistry · 2020 · 21 citations · 35 references

DOI

Concepts

References

35

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Lin‐Feng Chen, Wolfgang Fischle, Eric Verdin et al. · Science · 2001 · 1.2K citations · Full text

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

Jianyuan Luo, Fei Su, Delin Chen et al. · Nature · 2000 · 824 citations

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Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Paolo Serafini, Kristen F. Meckel, Michael J. Kelso et al. · The Journal of Experimental Medicine · 2006 · 754 citations · Full text

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HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Xiaohong Zhang, Zhigang Yuan, Yingtao Zhang et al. · Molecular Cell · 2007 · 725 citations · Full text

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Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

Yu Zhang, So-Hee Kwon, Teppei Yamaguchi et al. · Molecular and Cellular Biology · 2008 · 555 citations · Full text

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