Adam B. Keeton

Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/β-Catenin Signaling

Nan Li, Yaguang Xi, Heather N. Tinsley et al. · Molecular Cancer Therapeutics · 2013 · 134 citations · Full text

Medicine, Oncology, Pharmacology +17

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/β-Catenin–Mediated Transcription in Human Breast Tumor Cells

Heather N. Tinsley, Bernard D. Gary, Adam B. Keeton et al. · Cancer Prevention Research · 2011 · 112 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation

Wenyan Lü, Heather N. Tinsley, Adam B. Keeton et al. · European Journal of Pharmacology · 2008 · 106 citations

Medicine, Cancer Biology, Oncology +10

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

Heather N. Tinsley, Bernard D. Gary, Adam B. Keeton et al. · Molecular Cancer Therapeutics · 2009 · 100 citations · Full text

Medicine, Oncology, Pharmacology +14

A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity

Gary A. Piazza, Adam B. Keeton, Heather N. Tinsley et al. · Cancer Prevention Research · 2009 · 97 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13