Concepedia

The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells

Feixia Peng, Ying Zhou, Juan Wang, Baoqiang Guo, Yun Wei, Huan Deng, Zihui Wu, Cheng Zhang, Kaituo Shi, Yuan Li,

Journal of Biological Chemistry · 2020 · 49 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

P2. These findings indicate that Sp1 controls Pol III-directed transcription and shed light on how Sp1 regulates cancer cell proliferation.

References

30

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J. Bywater, Gretchen Poortinga, Elaine Sanij et al. · Cancer Cell · 2012 · 560 citations · Full text

, , +16

Direct activation of RNA polymerase III transcription by c-Myc

Natividad Gomez-Roman, Carla Grandori, Robert N. Eisenman et al. · Nature · 2003 · 438 citations

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Reduced O Glycosylation of Sp1 Is Associated with Increased Proteasome Susceptibility

Inn‐Oc Han, Jeffrey E. Kudlow · Molecular and Cellular Biology · 1997 · 435 citations · Full text

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RNA catalyses nuclear pre-mRNA splicing

Sebastian M. Fica, Nicole Tuttle, Thaddeus J. Novak et al. · Nature · 2013 · 345 citations · Full text

, , +9

Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer.

Liwei Wang, Daoyan Wei, Suyun Huang et al. · PubMed · 2003 · 336 citations

, , +9