Sebastian M. Fica - Concepedia

Author

Sebastian M. Fica

MRC Laboratory of Molecular Biology ORCID

Also Known As

S.M. Fica, Sebastian Fica, Sebastian M Fica, Sebastian M. Fica

Publications

1.7K

Citations

H-Index

Concepts

All Affiliations

MRC Laboratory of Molecular Biology University of Oxford University College London University of Chicago National Hospital for Neurology and Neurosurgery

About

Sebastian M. Fica is an author at MRC Laboratory of Molecular Biology specializing in molecular biology, natural sciences, and structural biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	3	3	386
2	Medicine	2	2	345
3	Biomolecular Engineering	2	2	150
4	Biology	1	1	12
5	Cell Biology	1	1	242

Sebastian M. Fica

Publications

1.4K

Citations

H-Index

Page 1

	Year	Citations
RNA catalyses nuclear pre-mRNA splicing Sebastian M. Fica, Nicole Tuttle, Thaddeus J. Novak, Nature Transcriptional RegulationNatural SciencesGeneticsRna SplicingRna Biology	2013	333
Cryo-EM structure of the spliceosome immediately after branching Wojciech P. Galej, Max E. Wilkinson, Sebastian M. Fica, Nature Molecular BiologyCellular StructureCryo-em StructureCell BiologySplicing Variant	2016	242
Structure of a spliceosome remodelled for exon ligation Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Nature Exon LigationMolecular BiologySplicing VariantRna ProcessingStructural Biology	2017	183
Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Science	2017	131
A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation Sebastian M. Fica, Chris Oubridge, Max E. Wilkinson, Science	2019	126
Evidence for a group II intron–like catalytic triplex in the spliceosome Sebastian M. Fica, Melissa A. Mefford, Joseph A. Piccirilli, Nature Structural & Molecular Biology Group IiMolecular BiologyMolecular GeneticsSplicing VariantRna Processing	2014	109
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome Yuyang Chen, Ruebena Dawes, Hyung Chul Kim, Nature	2024	93
m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site Matthew T Parker, Beth K Soanes, Jelena Kusakina, eLife	2022	61
Structural basis for conformational equilibrium of the catalytic spliceosome Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Molecular Cell	2021	60
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation Matthew J. Schellenberg, Tao Wu, Dustin B. Ritchie, Nature Structural & Molecular Biology Protein AssemblyNatural SciencesMetalloproteinMolecular BiologyConformational Switch	2013	41

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