Supporting clinical decision making in advanced melanoma by preclinical testing in personalized immune-humanized xenograft mouse models

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan et al. · Nature Medicine · 2018 · 5.4K citations · Full text

Cancer Immunosurveillance, T Cell Dysfunction, T-regulatory Cell +10

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

Răzvan Cristescu, Robin Mogg, Mark Ayers et al. · Science · 2018 · 2.3K citations

Checkpoint Blockade Immunotherapy, Immunology, Immune Cell Therapy +16

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao, Joshua M. Korn, Stéphane Ferretti et al. · Nature Medicine · 2015 · 1.4K citations

Tumor Biology, Radiology, Oncology +10

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi, Peter Forsyth, Alain P. Algazi et al. · New England Journal of Medicine · 2018 · 1.3K citations · Full text

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

Krijn K. Dijkstra, Chiara M. Cattaneo, Fleur Weeber et al. · Cell · 2018 · 1K citations · Full text

Tumor-reactive T Cells, Cell Therapy, Cancer Immunosurveillance +10