Concepedia

PAK1 silencing is synthetic lethal with CDK4/6 inhibition in gastric cancer cells via regulating PDK1 expression

Yan Qian, Xu Wu, Haixiao Wang, Guowei Hou, Xiao Han, Wei Song

Human Cell · 2020 · 13 citations · 22 references

Concepts

MedicineCancer BiologyOncologyCell SignalingMolecular OncologyTumor ProgressionCancer Cell SignalingGastric CancerOncogenic Signaling PathwaysSynthetic LethalitySynthetic Lethality In CancerCdk InhibitorsCdk4/6 DysregulationCdk4/6 HyperactivationResistance Mechanisms To Synthetic Lethal Therapy

References

22

Global cancer statistics

Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Medicine, Oncology, Cancer Epidemiology +15

Global Cancer Statistics, 2002

Donald Maxwell Parkin, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2005 · 18.4K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer

Valerie M. Jansen, Neil E. Bhola, Joshua A. Bauer et al. · Cancer Research · 2017 · 250 citations

Medicine, Oncology, Pharmacology +17

PAK signaling in cancer

Diana Zi Ye, Jeffrey Field · Cellular Logistics · 2012 · 230 citations · Full text

Medicine, Molecular Biology, Oncology +17

Pak1 Kinase Links ErbB2 to β-Catenin in Transformation of Breast Epithelial Cells

Luis E. Arias‐Romero, Olga Villamar‐Cruz, Min Huang et al. · Cancer Research · 2013 · 72 citations

Medicine, Cancer Biology, Oncology +16