Concepedia

Cdk4/6 Hyperactivation

CDK4/6 Hyperactivation is a molecular oncogenic event characterized by the aberrant and sustained activation of cyclin-dependent kinases 4 and 6, leading to dysregulated progression through the G1 phase of the cell cycle.

121

Publications

6.9K

Citations

1.3K

Authors

408

Institutions

Publications per year

2017–2026

77

Parents

Publications

121

An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)

Manav Korpal, Joshua M. Korn, Xueliang Gao et al. · Cancer Discovery · 2013 · 565 citations

, , +17

Requirement for CDK4 kinase function in breast cancer

Qunyan Yu, Ewa Sicińska, Yan Geng et al. · Cancer Cell · 2006 · 442 citations · Full text

, , +12

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

John P. Leonard, Ann S. LaCasce, Mitchell R. Smith et al. · Blood · 2012 · 297 citations · Full text

, , +14

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

Karen McColl, Gary Wildey, Nneha Sakre et al. · Oncotarget · 2017 · 162 citations · Full text

, , +17

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

Shenghui He, Patrick J. Roberts, Jessica A. Sorrentino et al. · Science Translational Medicine · 2017 · 154 citations

, , +16

1–5 of 121

Authors

1.3K

  1. SE
    Scott Ely

    Cornell University, United States

    3 publications · 326 citations

    3

    h-index

  2. GI
    Geoffrey I. Shapiro

    Dana-Farber Cancer Institute, United States

    3 publications · 452 citations

    3

    h-index

  3. SK
    Sunkyu Kim

    Korea University, South Korea

    3 publications · 751 citations

    3

    h-index

  4. SC
    Selina Chen‐Kiang

    Cornell University, United States

    3 publications · 326 citations

    3

    h-index

  5. SC
    Stephen Chia

    BC Cancer Agency, Canada

    2 publications · 52 citations

    2

    h-index

1–5 of 1.3K

Institutions

408

  1. Harvard University

    Cambridge, United States

    12 h-index

    58 publications

    15K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    12 h-index

    77 publications

    16.1K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    8 h-index

    18 publications

    1.4K citations

  4. Massachusetts General Hospital

    Boston, United States

    5 h-index

    6 publications

    234 citations

  5. Brigham and Women's Hospital

    Boston, United States

    5 h-index

    12 publications

    2.4K citations

  6. Universität Hamburg

    Hamburg, Germany

    5 h-index

    12 publications

    682 citations

  7. Dana-Farber Brigham Cancer Center

    Boston, United States

    5 h-index

    5 publications

    954 citations

  8. University Hospital Ulm

    Ulm, Germany

    4 h-index

    4 publications

    119 citations

1–8 of 408

Venues

  1. Clinical Cancer Research

    8 publications · 537 citations

    8

    h-index

  2. Cancer Research

    6 publications · 150 citations

    6

    h-index

  3. Oncogene

    6 publications · 400 citations

    6

    h-index

  4. Journal of Clinical Oncology

    7 publications · 182 citations

    6

    h-index

  5. Blood

    6 publications · 511 citations

    6

    h-index

1–5