Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Kévin Pethe, Pablo Bifani, Jichan Jang et al. · Nature Medicine · 2013 · 614 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

Damien Portevin, Célia Regina Sousa da Silva, Christine Houssin et al. · Proceedings of the National Academy of Sciences · 2003 · 387 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

Thomas R. Ioerger, Theresa O’Malley, Reiling Liao et al. · PLoS ONE · 2013 · 251 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +14

Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents

Mohamed Jawed Ahsan, Jeyabalan Govinda Samy, Habibullah Khalilullah et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 200 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Anup Aggarwal, Maloy Kumar Parai, N.D. Shetty et al. · Cell · 2017 · 182 citations · Full text

Pharmacy, Chemistry, Molecular Biology +12