Concepedia

Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit

Simon O. R. Greenwood, A. W. Edith Chan, D. Flemming Hansen, Charles M. Marson

Bioorganic & Medicinal Chemistry Letters · 2020 · 14 citations · 26 references

DOIFull text

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Concepts

References

26

The language of covalent histone modifications

Brian D. Strahl, C. David Allis · Nature · 2000 · 8.6K citations

, , +12

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Jack Taunton, Christian A. Hassig, Stuart L. Schreiber · Science · 1996 · 1.8K citations

, , +10

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Medicinal Chemistry · 2012 · 1.3K citations · Full text

, , +15

Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer

William Kevin Kelly, Owen A. O’Connor, Lee M. Krug et al. · Journal of Clinical Oncology · 2005 · 907 citations · Full text

, , +16

Mutations truncating the EP300 acetylase in human cancers

Simon A. Gayther, Sarah J. Batley, Lori Linger et al. · Nature Genetics · 2000 · 593 citations

, , +12