Concepedia

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H. Dillingham, Bernadette A. Chua, Miriama Krutá, Yuning Hong, Danny M. Hatters, Robert Signer

Cell Reports · 2020 · 106 citations · 52 references

DOIFull text

Open access

Concepts

Abstract

HSCs. Thus, HSCs are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.

References

52

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

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The Sequence Alignment/Map format and SAMtools

Heng Li, Alec Wysoker, Tim Fennell et al. · Bioinformatics · 2009 · 67.5K citations · Full text

, , +17

HTSeq—a Python framework to work with high-throughput sequencing data

Simon Anders, Paul Theodor Pyl, Wolfgang Huber · Bioinformatics · 2014 · 22.7K citations · Full text

, , +11

TopHat: discovering splice junctions with RNA-Seq

Cole Trapnell, Lior Pachter, Steven L. Salzberg · Bioinformatics · 2009 · 12.1K citations · Full text

, , +16

Quality control and preprocessing of metagenomic datasets

Robert Schmieder, Robert A. Edwards · Bioinformatics · 2011 · 5.4K citations · Full text

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