Prothrombin Arg541Trp Mutation Leads to Defective PC (Protein C) Pathway Activation and Constitutes a Novel Genetic Risk Factor for Venous Thrombosis - Concepedia

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Prothrombin Arg541Trp Mutation Leads to Defective PC (Protein C) Pathway Activation and Constitutes a Novel Genetic Risk Factor for Venous Thrombosis

DOI Full Paper Access

15

Citations

22

References

2019

Year

Xi Wu, Jing Dai, Xiaoqian Xu, Fang Li, Lei Li, Yeling Lu, Qin Xu, Qiulan Ding, Wenman Wu, Xuefeng Wang

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

In summary, the prothrombin p.Arg541Trp mutation constitutes a new genetic risk factor of VTE by impairing function of PC pathway and tilting thrombin's procoagulant activity over anticoagulant function.

References

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