Concepedia

Prothrombin Gene Mutation

Prothrombin Gene Mutation is a genetic variant in the prothrombin (F2) gene characterized by a specific single nucleotide substitution (G20210A) that increases prothrombin plasma levels and confers a heightened risk for venous thrombosis.

1.3K

Publications

69.9K

Citations

5.9K

Authors

1.4K

Institutions

Publications per year

2017–2026

74

Variants

F2 Gene Mutation

Parents

Publications

1.3K

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

SR Poort, FR Rosendaal, PH Reitsma et al. · Blood · 1996 · 3.1K citations · Full text

, , +15

Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis

Jeanet W. Blom · JAMA · 2005 · 2K citations

, , +14

Geographic Distribution of the 20210 G to A Prothrombin Variant

Carine J.M. Doggen, Ariella Zivelin, Valder R. Arruda et al. · Thrombosis and Haemostasis · 1998 · 702 citations · Full text

, , +17

High Risk of Cerebral-Vein Thrombosis in Carriers of a Prothrombin-Gene Mutation and in Users of Oral Contraceptives

Ida Martinelli, Elisabetta Sacchi, G Landi et al. · New England Journal of Medicine · 1998 · 655 citations · Full text

, , +17

Ethnic Distribution of Factor V Leiden in 4047 Men and Women

Paul M. Ridker · JAMA · 1997 · 642 citations

, , +17

1–5 of 1.3K

Authors

5.9K

  1. FR
    Frits R. Rosendaal

    Leiden University Medical Center, Netherlands

    33 publications · 4.5K citations

    27

    h-index

  2. PM
    Pier Mannuccio Mannucci

    University of Milan, Italy

    31 publications · 3.7K citations

    26

    h-index

  3. VD
    Valerio De Stefano

    Università Cattolica del Sacro Cuore, Italy

    25 publications · 2.8K citations

    20

    h-index

  4. IM
    Ida Martinelli

    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Italy

    20 publications · 3.1K citations

    19

    h-index

  5. DA
    David A. Lane

    Charing Cross Hospital, United Kingdom

    20 publications · 1.6K citations

    17

    h-index

1–5 of 5.9K

Institutions

1.4K

  1. Leiden University Medical Center

    Leiden, The Netherlands

    31 h-index

    152 publications

    23.5K citations

  2. University of Milan

    Milan, Italy

    25 h-index

    109 publications

    11.1K citations

  3. Inserm

    Paris, France

    23 h-index

    173 publications

    11K citations

  4. Lund University

    Lund, Sweden

    19 h-index

    58 publications

    4.5K citations

  5. Ankara University

    Ankara, Türkiye

    18 h-index

    75 publications

    2.5K citations

  6. Harvard University

    Cambridge, United States

    17 h-index

    60 publications

    4.6K citations

  7. Amsterdam UMC Location University of Amsterdam

    Amsterdam, The Netherlands

    17 h-index

    78 publications

    7.9K citations

  8. Casa Sollievo della Sofferenza

    San Giovanni Rotondo, Italy

    16 h-index

    69 publications

    7.2K citations

1–8 of 1.4K

Venues

  1. Thrombosis and Haemostasis

    137 publications · 8.7K citations

    49

    h-index

  2. Blood

    96 publications · 9.6K citations

    46

    h-index

  3. PubMed

    Repository · 103 publications · 3.6K citations

    33

    h-index

  4. British Journal of Haematology

    BJH · 60 publications · 3.7K citations

    32

    h-index

  5. Journal of Thrombosis and Haemostasis

    JTH · 44 publications · 1.9K citations

    29

    h-index

1–5