Concepedia

Structural modification of the aryl sulfonate ester of cjoc42 for enhanced gankyrin binding and anti-cancer activity

Dipti Kanabar, Pamela Farrales, Manu Gnanamony, Joseph Almasri, Ehab M. Abo‐Ali, Younos Otmankel, Henna Shah, Dawn Nguyen, Mark El Menyewi, Vikas V. Dukhande,

Bioorganic & Medicinal Chemistry Letters · 2019 · 29 citations · 23 references

DOI

Concepts

References

23

Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

Hiroaki Higashitsuji, Katsuhiko Itoh, Toshikazu Nagao et al. · Nature Medicine · 2000 · 298 citations

, , +14

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

Hiroaki Higashitsuji, Hisako Higashitsuji, Katsuhiko Itoh et al. · Cancer Cell · 2005 · 229 citations · Full text

, , +6

Chaperone-mediated pathway of proteasome regulatory particle assembly

Jeroen Roelofs, Soyeon Park, Wilhelm Haas et al. · Nature · 2009 · 188 citations · Full text

, , +14

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome

Simon Dawson, Sébastien Apcher, Maureen Mee et al. · Journal of Biological Chemistry · 2002 · 120 citations · Full text

, , +10

Use of Adenovirus-Delivered siRNA to Target Oncoprotein p28GANK in Hepatocellular Carcinoma

Honghai Li, Xiaoyong Fu, Chen Yao et al. · Gastroenterology · 2005 · 97 citations · Full text

, , +17