Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren's syndrome highlight T cell-initiated autoimmunity

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

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Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

Benjamin Joachim Schmiedel, Divya Singh, Ariel Madrigal et al. · Cell · 2018 · 965 citations · Full text

Life Sciences, Genetics, Immunology +17

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 475 citations · Full text

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Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

Idit Sagiv-Barfi, Holbrook E. Kohrt, Debra K. Czerwinski et al. · Proceedings of the National Academy of Sciences · 2015 · 446 citations · Full text

Medicine, Oncology, Pharmacology +17

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

Takumi Maruhashi, Il‐mi Okazaki, Daisuke Sugiura et al. · Nature Immunology · 2018 · 276 citations

Life Sciences, Immunology, Molecular Biology +15