Concepedia

Recruitment of CD103 <sup>+</sup> dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

John‐Michael Williford, Jun Ishihara, Ako Ishihara, Aslan Mansurov, Peyman Hosseinchi, Tiffany M. Marchell, Lambert Potin, Melody A. Swartz, Jeffrey A. Hubbell

Science Advances · 2019 · 132 citations · 24 references

DOIFull text

Open access

Concepts

Abstract

T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. Thus, CBD-CCL4 holds clinical translational potential by enhancing efficacy of CPI immunotherapy.

References

24

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

James Larkin, Vanna Chiarion‐Sileni, René González et al. · New England Journal of Medicine · 2015 · 8.1K citations · Full text

, , +17

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan, Shannon J. Turley, Dorothee Nickles et al. · Nature · 2018 · 5.5K citations

, , +16

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

Stefani Spranger, Riyue Bao, Thomas F. Gajewski · Nature · 2015 · 2.8K citations

, , +10

<i>Batf3</i> Deficiency Reveals a Critical Role for CD8α <sup>+</sup> Dendritic Cells in Cytotoxic T Cell Immunity

Kai Hildner, Brian T. Edelson, Whitney E. Purtha et al. · Science · 2008 · 2K citations

, , +17

Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy

Stefani Spranger, Daisy Dai, Brendan Horton et al. · Cancer Cell · 2017 · 1.4K citations · Full text

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